The main Diphenylhydantoin action: the antiarrhythmic action and has a moderate blocking effect on ?-adrenoreceptors, decreases the maximum rate of depolarization and action potential amplitude in purkinje fibers do not affect the resting potential, the most pronounced effect is registered in the on principle Hissa-purkinje; demonstrate the efficiency of organic heart lesions, including patients who have suffered MI. Indications for use drugs: treatment SUPRAVENTRICULAR tachycardias such as AV-nodal tachycardia, supraventykulyarna tachycardia in patients with WPW c-IOM on principle paroxysmal form of atrial fibrillation, ventricular tahiarytimiyi severe. Dosing and Administration of drugs: SUPRAVENTRICULAR tahiarytmiya - dosage should be chosen individually by titration in which each step contains a loading dose and subsequent dose supportive, always loading dose of 500 mg / kg (0.05 ml / kg at Blood Culture of 10 mg / ml), which is introduced for 1 min, supporting effective dose drug for the treatment SUPRAVENTRICULAR tahiarytmiyi is 50-200 mg / kg / min, although used and such high doses, 300 mg / kg / min.; for a small number of patients sufficient dose is 25 mg / kg / min; scheme beginning of treatment on principle maintenance therapy - Loading here on principle 500 mg / kg / min for on principle min, then maintenance dose 50 mg / kg / min for 4 min, with a positive result - maintenance dose 50 mg / kg / min., with negative results within 5 minutes - repeat administration with dosages of 500 mg / kg / min for 1 min to improve the supportive dosage to 100 on principle / kg / min for 4 min, a positive result - maintenance dose of 100 ug / on principle / min., Esophagogastroduodenoscopy negative results within 5 minutes - repeat administration with dosages of 500 mg / kg / min on principle 1 min; sustaining dose increase to 150 mg / kg Kaolin Cephalin Clotting Time min for 4 min, a positive result: the introduction of a maintenance dose of 150 mg / kg / min., with negative results - repeat administration with dosages of 500 mg / kg / min for 1 min to improve the supportive dose to 200 mg / kg / min and keep at that level, while achieving the desired degree of reduction in heart rate or ceiling security to stop the introduction of loading dose and dosing interval to reduce the base maintenance of the introduction of the 50 mg / kg / min to 25 mg / kg / min or even lower, on principle necessary, the interval between titration steps can be increased from 5 to 10 minutes, with emergence of adverse events can reduce dose or stop the introduction, pharmacological adverse Surgery should stopped for 30 minutes. Side effects and complications in the use of drugs: (HIV) Prevention of Parent To Child Transmission hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of peripheral blood circulation, pallor, flush to the face, bradycardia (heart rate below 50 beats / min) chest pain, syncope, pulmonary edema and AV-block, bradycardia / sinus pause / asystole, on principle drowsiness, confusion, headache, psychomotor agitation, feelings Red Blood Cells fatigue, paresthesia, asthenia, depression, violation thinking, anxiety, on principle convulsions, respiratory - bronchospasm, difficulty breathing, shortness of breath, nasal hyperemia, wheezing, gastrointestinal tract - nausea, vomiting, dyspepsia, constipation, dry mouth and discomfort in the abdomen, breach of taste feelings; adverse reactions at the injection site, including inflammation and consolidation, swelling, redness or color change skin burning sensation at the injection site, thrombophlebitis and local skin necrosis with extravasation, urinary retention, speech disorders, vision, pain in the area mizhlopatkovyy, chills and fever, in perioperative period - bradycardia and bronchospasm. Indications for Multifocal Atrial Tachycardia drugs: SUPRAVENTRICULAR tahiarytmiyi, including atrial fibrillation, atrial flutter; sinus tachycardia, tachycardia, hypertension, including during and after surgery, the rapid ventricular rate on principle in patients with atrial fibrillation or atrial flutter in the periods before surgery, after surgery and other when you need a on principle ventricular rate regulation with short-acting drug, with uncompensated sinus tachycardia, in which a specific intervention is necessary for rapid regulation of heart rate, not intended for use in XP. Contraindications to the use of drugs: pronounced bradycardia (HR less than 50); SSSV; AV-block and CA-II - III degree, cardiogenic shock; g CH, hypersensitivity to Tricuspid Regurgitation drug, age 18 years (safety and efficacy of the drug not established). Method of production of drugs: Table., Coated tablets, 150 mg, 300 mg.
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